Moshe Talpaz Selected Research

Philadelphia Chromosome

12/2019	Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.
1/2018	Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial.
10/2017	Effects of Bosutinib Treatment on Renal Function in Patients With Philadelphia Chromosome-Positive Leukemias.
1/2017	Induction of p53 suppresses chronic myeloid leukemia.
1/2016	Impact of dose intensity of ponatinib on selected adverse events: Multivariate analyses from a pooled population of clinical trial patients.
1/2016	Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.
1/2014	Ponatinib in Philadelphia chromosome-positive leukemias.
11/2013	Sequential therapy in chronic myelogenous leukemia: where do emerging therapies fit within current treatment regimens?
11/2012	Ponatinib in refractory Philadelphia chromosome-positive leukemias.
12/2007	Strategies for overcoming imatinib resistance in chronic myeloid leukemia.

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Moshe Talpaz Research Topics

Disease

93	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2000
43	Philadelphia Chromosome 12/2019 - 02/2002
40	Neoplasms (Cancer) 04/2021 - 05/2003
35	Primary Myelofibrosis (Myelosclerosis) 01/2022 - 03/2003
22	Leukemia 12/2021 - 03/2003
13	Thrombocytopenia (Thrombopenia) 01/2022 - 09/2002
10	Splenomegaly 01/2021 - 10/2004
10	Anemia 01/2020 - 04/2002
10	Disease Progression 12/2019 - 03/2002
9	Multiple Myeloma 12/2019 - 03/2003
7	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 06/2003
7	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018 - 06/2004
7	Blast Crisis (Blast Phase) 02/2011 - 05/2002
6	Fatigue 01/2020 - 06/2003
5	Neutropenia 01/2016 - 06/2003
4	Melanoma (Melanoma, Malignant) 02/2021 - 04/2007
4	Fibrosis (Cirrhosis) 01/2021 - 07/2004
4	Pancreatitis 12/2019 - 11/2012
3	Nausea 01/2020 - 12/2003
3	Diarrhea 01/2017 - 12/2003
3	Genetic Translocation (Chromosomal Translocation) 01/2017 - 04/2015
3	Exanthema (Rash) 01/2016 - 08/2014
3	Polycythemia Vera 08/2015 - 06/2003
3	Hematologic Neoplasms (Hematological Malignancy) 06/2013 - 02/2003
3	Chromosome Aberrations (Chromosome Abnormalities) 12/2010 - 05/2002
3	Residual Neoplasm 10/2007 - 01/2003
2	Carcinoma (Carcinomatosis) 04/2021 - 01/2019
2	Wernicke Encephalopathy (Wernicke's Encephalopathy) 01/2021 - 07/2017
2	Myeloid Leukemia (Leukemia, Myelocytic) 01/2020 - 02/2013
2	Inflammation (Inflammations) 01/2020 - 08/2003
2	Cytopenia 12/2019 - 05/2002
2	Leukocytosis (Pleocytosis) 08/2015 - 12/2003
2	Essential Thrombocythemia 03/2011 - 06/2005
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2003 - 06/2003
2	Edema (Dropsy) 12/2003 - 08/2002
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 05/2003 - 08/2002
1	Hemorrhage 01/2022

Drug/Important Bio-Agent (IBA)

70	Imatinib Mesylate (Gleevec)FDA Link 10/2017 - 01/2000
22	ruxolitinibIBA 01/2022 - 03/2012
21	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2003
17	Phosphotransferases (Kinase)IBA 12/2019 - 01/2003
15	Proteins (Proteins, Gene)FDA Link 02/2021 - 03/2002
15	Interferon-alpha (Interferon Alfa)IBA 04/2015 - 01/2000
9	fedratinibIBA 01/2022 - 03/2011
9	bcr-abl Fusion ProteinsIBA 11/2013 - 01/2000
8	Janus Kinase InhibitorsIBA 01/2022 - 04/2013
7	InterferonsIBA 12/2021 - 06/2003
7	ponatinibIBA 11/2021 - 11/2012
7	CytokinesIBA 01/2021 - 07/2003
7	Dasatinib (BMS 354825)FDA Link 01/2018 - 10/2005
7	Pharmaceutical PreparationsIBA 06/2015 - 05/2002
6	Deubiquitinating EnzymesIBA 02/2021 - 11/2010
5	Janus Kinase 2IBA 05/2021 - 12/2013
5	DNA (Deoxyribonucleic Acid)IBA 04/2021 - 12/2010
5	Transcription Factors (Transcription Factor)IBA 02/2021 - 08/2003
5	Biological ProductsIBA 01/2021 - 12/2003
5	Janus Kinase 1IBA 01/2018 - 10/2013
5	degrasynIBA 06/2015 - 04/2007
5	Cytarabine (Cytosar-U)FDA LinkGeneric 09/2005 - 05/2002
4	Janus KinasesIBA 01/2022 - 03/2012
4	NF-kappa B (NF-kB)IBA 01/2021 - 08/2003
4	Lipase (Acid Lipase)FDA Link 12/2019 - 11/2012
3	11- (2- pyrrolidin- 1- ylethoxy)- 14,19- dioxa- 5,7,26- triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23- decaeneIBA 01/2022 - 01/2018
3	RNA (Ribonucleic Acid)IBA 04/2021 - 11/2011
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2021 - 07/2014
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 11/2013
3	Erythropoietin FDA Link 10/2013 - 04/2002
3	Reticulin (Reticular Fiber)IBA 08/2005 - 07/2004
3	Hemoglobins (Hemoglobin)IBA 05/2005 - 04/2002
2	LigandsIBA 10/2019 - 12/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2019 - 08/2003
2	glasdegibIBA 06/2019 - 01/2019
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 02/2002
2	INCB039110IBA 01/2018 - 01/2017
2	nilotinib FDA Link 01/2018 - 01/2007
2	Proteasome InhibitorsIBA 01/2016 - 08/2014
2	marizomibIBA 01/2016 - 08/2014
2	Bortezomib (Velcade)FDA Link 08/2014 - 10/2009
2	UbiquitinIBA 12/2011 - 08/2011
2	Biomarkers (Surrogate Marker)IBA 11/2011 - 02/2008
2	Tyrosine (L-Tyrosine)FDA Link 04/2008 - 10/2005
2	Protein Isoforms (Isoforms)IBA 12/2006 - 01/2004
2	TransferasesIBA 01/2006 - 03/2003
2	Decitabine FDA Link 06/2005 - 08/2003
2	tipifarnib (R115777)IBA 12/2003 - 03/2003
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2003 - 02/2002
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2003 - 07/2003
2	HomoharringtonineIBA 09/2003 - 04/2002
1	Interleukin-1 Receptor-Associated KinasesIBA 01/2022
1	AntigensIBA 12/2021
1	EnzymesIBA 02/2021
1	Ubiquitin-Specific ProteasesIBA 02/2021

Therapy/Procedure

83	Therapeutics 01/2022 - 04/2002
4	Drug Tapering 01/2018 - 06/2003
3	Stem Cell Transplantation 07/2003 - 09/2002
2	Cell Transplantation 12/2021 - 12/2020
2	Precision Medicine 09/2015 - 03/2008
2	Drug Therapy (Chemotherapy) 12/2006 - 03/2005
2	Aftercare (After-Treatment) 02/2003 - 08/2002
1	Homologous Transplantation 12/2021